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Undesirable substances can be hazardous to health. Based on opinions of international committees specialized in food toxicology, how to define dietary risk for any substance set an acceptable daily intake (ADI). This is the maximum dose of this substance may be ingested daily over a lifetime without risk to health. Reported per kilogram of body weight, this dose is deducted from the maximum dose without detectable adverse effects (DMSE) of the substance determined in the species most appropriate, which is applied by a factor of safety. (more…)